The functional dark side of genomes and metagenomes


Unifying the known and unknown coding sequence space in microbiome analyses

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Illuminating the functional dark side


By connecting genomic and metagenomic gene clusters in a single framework, our approach reveals the ecology, biogeography, and taxonomic affiliations of unknown gene clusters, providing comprehensive access to vast amounts of unknown biology through an extensible and scalable database.

A World of Unknowns


1,835

Metagenomes

28,941

Genomes

416M

Genes

75M

Unknowns

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